ASIR: Robust Agent-based Representation Of SIR Model

Compartmental models (written as $CM$) and agent-based models (written as $AM$) are dominant methods in the field of epidemic simulation. But in the literature there lacks discussion on how to build the \textbf{quantitative relationship} between them. In this paper, we propose an agent-based $SIR$ model: $ASIR$. $ASIR$ can robustly reproduce the infection curve predicted by a given SIR model (the simplest $CM$.) Notably, one can deduce any parameter of $ASIR$ from parameters of $SIR$ without manual tuning. $ASIR$ offers epidemiologists a method to transform a calibrated $SIR$ model into an agent-based model that inherit $SIR$'s performance without another round of calibration. The design $ASIR$ is inspirational for building a general quantitative relationship between $CM$ and $AM$

TAG : Type Auxiliary Guiding for Code Comment Generation

Existing leading code comment generation approaches with the structure-to-sequence framework ignores the type information of the interpretation of the code, e.g., operator, string, etc. However, introducing the type information into the existing framework is non-trivial due to the hierarchical dependence among the type information. In order to address the issues above, we propose a Type Auxiliary Guiding encoder-decoder framework for the code comment generation task which considers the source code as an N-ary tree with type information associated with each node. Specifically, our framework is featured with a Type-associated Encoder and a Type-restricted Decoder which enables adaptive summarization of the source code. We further propose a hierarchical reinforcement learning method to resolve the training difficulties of our proposed framework. Extensive evaluations demonstrate the state-of-the-art performance of our framework with both the auto-evaluated metrics and case studies.Comment: ACL 2020, Accepte

Limited Information Aggregation and Externalities - A Simple Model of Metastable Market

We analyze a model in which agents’ decisions to enter or exit investments are influenced from their individual and external parties’ transaction histories. Actual investment outcomes are unknown to all participants until the end of decision periods, but outcomes do change depending on the number of participating players in the market and the market’s current state of condition. In this particular model, agents have access to external parties’ information from those who are within their specific social network. Our study of limited information aggregation mainly focuses on market responses to investors’ decisions of exiting the investment. With social structures complicating investment outcomes, we present a model that describes how markets can enter relatively stable statuses long enough for exiting participants to return, which brings the investment back to normal conditions. Our model also supports previous studies that limited information aggregation can cause the exogenous shock effect of global collapse

Limited Information Aggregation and Externalities - A Simple Model of Metastable Market

We analyze a model in which agents’ decisions to enter or exit investments are influenced from their individual and external parties’ transaction histories. Actual investment outcomes are unknown to all participants until the end of decision periods, but outcomes do change depending on the number of participating players in the market and the market’s current state of condition. In this particular model, agents have access to external parties’ information from those who are within their specific social network. Our study of limited information aggregation mainly focuses on market responses to investors’ decisions of exiting the investment. With social structures complicating investment outcomes, we present a model that describes how markets can enter relatively stable statuses long enough for exiting participants to return, which brings the investment back to normal conditions. Our model also supports previous studies that limited information aggregation can cause the exogenous shock effect of global collapse

Data Driven Chiller Plant Energy Optimization with Domain Knowledge

Refrigeration and chiller optimization is an important and well studied topic in mechanical engineering, mostly taking advantage of physical models, designed on top of over-simplified assumptions, over the equipments. Conventional optimization techniques using physical models make decisions of online parameter tuning, based on very limited information of hardware specifications and external conditions, e.g., outdoor weather. In recent years, new generation of sensors is becoming essential part of new chiller plants, for the first time allowing the system administrators to continuously monitor the running status of all equipments in a timely and accurate way. The explosive growth of data flowing to databases, driven by the increasing analytical power by machine learning and data mining, unveils new possibilities of data-driven approaches for real-time chiller plant optimization. This paper presents our research and industrial experience on the adoption of data models and optimizations on chiller plant and discusses the lessons learnt from our practice on real world plants. Instead of employing complex machine learning models, we emphasize the incorporation of appropriate domain knowledge into data analysis tools, which turns out to be the key performance improver over state-of-the-art deep learning techniques by a significant margin. Our empirical evaluation on a real world chiller plant achieves savings by more than 7% on daily power consumption.Comment: CIKM2017. Proceedings of the 26th ACM International Conference on Information and Knowledge Management. 201

SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner

As one of the most common post-transcriptional modifications of mRNAs and noncoding RNAs, N6-methyladenosine (m6A) modification regulates almost every aspect of RNA metabolism. Evidence indicates that dysregulation of m6A modification and associated proteins contributes to glioblastoma (GBM) progression. However, the function of fat mass and obesity-associated protein (FTO), an m6A demethylase, has not been systematically and comprehensively explored in GBM. Here, we found that decreased FTO expression in clinical specimens correlated with higher glioma grades and poorer clinical outcomes. Functionally, FTO inhibited growth and invasion in GBM cells in vitro and in vivo. Mechanistically, FTO regulated the m6A modification of primary microRNA-10a (pri-miR-10a), which could be recognized by reader HNRNPA2B1, recruiting the microRNA microprocessor complex protein DGCR8 and mediating pri-miR-10a processing. Furthermore, the transcriptional activity of FTO was inhibited by the transcription factor SPI1, which could be specifically disrupted by the SPI1 inhibitor DB2313. Treatment with this inhibitor restored endogenous FTO expression and decreased GBM tumor burden, suggesting that FTO may serve as a novel prognostic indicator and therapeutic molecular target of GBM.publishedVersio